MyBioSource.com's Mouse Monoclonal [clone 10.32] (IgG2b) to Human UMOD / Uromodulin is a Mouse monoclonal antibody. The Mouse Monoclonal [clone 10.32] (IgG2b) to Human UMOD / Uromodulin Antibody was generated using HNFJ, MCKD2, THP, UMOD, uromodulin, and Uromucoid as the antigen. It reacts with Human, and Canine. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
This product is a monoclonal antibody which reacts with an epitope of the urinary mucoprotein. Tamm-Horsfall protein is a glycoprotein of approximately 80 kDa containing up to 25% carbohydrate by weight. It exists as a high molecular weight polymer in urine and approximately 50 mg of the THP are excreted per day by adult humans. THP is produced by the epithelial cells lining the thick ascending loop of Henle and distal convoluted tubules of the kidney. THP is also the primary constituent of renal tubular casts and THP aggregation has been implicatedas a factor in the pathogenesis of acute renal failure by causing tubular. obstruction. Antibody to THP is present in the serum of patients with pyelonephritis and reflus uropathy. This monoclonal antibody has shown good localization to the distal tubule and collecting duct as well as to large deposits of Tamm-Horsfall protein which has clogged peri-pelvic veins. This antibody also works with canine. Total protein concentration (including BSA) is 4-5 mg/ml